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KMID : 0370220110550060446
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Yakhak Hoeji
2011 Volume.55 No. 6 p.446 ~ p.450
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Synthesis and -Glucosidase Inhibitory Activity of Phenylalkyl Piperazine Analogues
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Chang In-Hye
Lee Eun-Young
Hwang Bo-Kyoung
Kim In-Kyu
Sohn Kyung-Hee
Choi Lan
Lee Eung-Seok
Woo Mi-Hee
Son Jong-Keun
Na Young-Hwa
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Abstract
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As an effort to find a new scaffold for -glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their -glucosidase inhibitory activities. Compounds 8 () possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to -glucosidase. The result indicated that proper substituents on the piperazine can engender -glucosidase inhibitory activities on the piperazine derivatives.
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KEYWORD
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-glucosidase, piperazine analogues, type 2 diabetes
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